CoGenesis® ASD
A comprehensive ASD and neurodevelopmental panel-1,255 SFARI-curated genes
CoGenesis® ASD provides a comprehensive look at genetic factors linked to autism and related neurodevelopmental conditions. It analyzes 1,255 genes from the SFARI Gene database, helping to identify both common and rare genetic variants. In addition, the report includes polygenic risk scores (PRS) for Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Epilepsy. These scores summarize the combined effect of many genetic markers, offering a broader picture of inherited risk. Together, the rare genetic variant analysis and PRS profiling give families and clinicians valuable insights into genetic contributions to neurodevelopmental issue.
- Comprehensive genetic evaluation of autism spectrum disorder (ASD) and related neurodevelopmental conditions
- Analysis of 1,255 genes from the SFARI Gene database to detect both common and rare variants
- Providing polygenic risk scores (PRS) for ADHD, ASD, and Epilepsy to assess cumulative genetic risk
- Supporting clinicians and families with insights into genetic contributions to neurodevelopmental health
-Diagnosis of non-genetic causes of ASD or related conditions -Predicting behavioral outcomes or disease severity with certainty -Serving as a stand-alone diagnostic tool without clinical correlation -Identifying environmental or lifestyle factors contributing to neurodevelopmental disorders
| Step / Test | Accuracy | Notes |
|---|---|---|
| SNP Genotyping | >99.9% | |
| INDEL Calling | >99% |
4mL Peripheral blood (EDTA), 2mL saliva, or buccal swab
Preferred sample type:
- 4mL Blood (EDTA tube),
- Codex-provided buccal swabs (4 swabs)
- Codex-provided saliva collection kit (2mL)
Saliva or buccal swab sample collection: Follow the enclosed instructions; do not eat, drink, or smoke for 30 minutes before collection.
- Insufficient DNA quantity or poor DNA quality
- Improperly labeled or contaminated samples
- Degraded specimens due to incorrect storage or transport
- Non-human samples or inappropriate specimen types
Samples must be collected and submitted by a licensed healthcare professional.
- Keep Blood samples at 4–8°C after collection; avoid freezing, deliver within 48 hours of collection.
- Saliva or buccal swabs are stability in room temperature for up to 7 days. Address: Unit 220, 2/F, Building 16W, HKSTP, Pak Shek Kok, NT, Hong Kong. Tel: +852 3008 2560
- Results may identify pathogenic, likely pathogenic, or variants of uncertain significance (VUS) within the analyzed genes.
- Polygenic risk scores provide a relative measure of genetic predisposition compared to general population averages.
- Findings should be interpreted in the context of clinical history, developmental assessments, and other diagnostic information.
- Genetic counseling is recommended to help families understand the implications of both rare variant findings and polygenic risk scores.
Autism spectrum disorder and related neurodevelopmental conditions have complex genetic underpinnings involving both rare variants and common polygenic influences. CoGenesis® ASD integrates targeted sequencing of 1,255 genes curated from the SFARI Gene database with polygenic risk scores for ADHD, ASD, and Epilepsy. This dual approach enables a comprehensive genetic profile, offering clinicians and families a clearer understanding of inherited risk factors and potential pathways involved in neurodevelopmental health.
Hong Kong-based molecular diagnostics laboratory specialising in clinical genomics, precision oncology, and rare disease diagnosis. Accredited to ISO 27001 and GenQA standards.
© 2026 Codex Genetics Limited. All rights reserved.
