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Cancer Screening

Cxbladder® Triage Plus

Urine genomic test to risk-stratify haematuria — AUA Guideline Level A Evidence

Turnaround Time2 working weeks
🧪Specimen TypeUrine
🔬MethodRT-PCR gene expression analysis (5-gene mRNA panel)
AccreditationsCLIA-certified
Cxbladder® Triage Plus

Cxbladder® Triage Plus is a non-invasive urine genomic test that measures the expression of five biomarker genes (CDC2, IGFBP5, HOXA13, MDK, CXCR2) to determine the likelihood of urothelial cancer. It is recommended in the 2020 American Urological Association (AUA) Microhaematuria Guideline as the first and only urine-based genomic biomarker test supported by Level A Evidence.

Patients presenting to urologic care with haematuria (visible or non-visible) requiring risk stratification to guide the need for cystoscopy. Suitable for use in primary care and urology settings to de-intensify work-up in low-risk patients.

⚠ Not intended for: Not for patients with active urinary tract infection. Not a replacement for cystoscopy in high-risk patients. Not intended for population-level asymptomatic screening.

CDC2, IGFBP5, HOXA13, MDK, CXCR2 (5-gene mRNA expression panel)

Specimen Type: Urine

30–50 mL midstream urine collected into the Cxbladder collection tube (contains preservative). Do not use catheter samples.

Available through Codex Genetics as the authorised Pacific Edge distributor in Hong Kong. Please contact us for test kits, collection instructions, and ordering.

Shipping Instructions:

Cxbladder specimens must be collected using the dedicated Cxbladder collection kit.

  1. Request a collection kit from your healthcare provider or Codex Genetics.
  2. Collect midstream urine (30–50 mL) into the provided tube with preservative.
  3. Seal securely; store at room temperature.
  4. Deliver to Codex Genetics Laboratory within 5 days of collection. Address: Unit 220, 2/F, Building 16W, HKSTP, Pak Shek Kok, NT, Hong Kong.

Please contact us for pricing.

Bladder cancer is the 10th most common cancer globally. Haematuria is the most common presenting symptom, but most patients with haematuria do not have bladder cancer. The AUA 2020 Microhaematuria Guideline recommends Cxbladder Triage Plus as a Level A Evidence urine biomarker test to risk-stratify patients and reduce unnecessary invasive investigations. The test analyses gene expression of IGFBP5, HOXA13, MDK, CDC2, and CXCR2.