What factors affect drug response?
In addition to the expected effects after taking the drug, there may be unwanted side effects, including toxic reactions or allergic reactions. Everyone has the chance to respond differently to the same type and dose of drugs, which are affected by external or internal factors. An example of an external factor is when the patient is taking other drugs at the same time, where drug interaction may occur. Additionally, further drug reactions may occur depending on the type of food and drink consumed. Internal, personal factors which may affect response to drug intake include height, weight, age, other diseases that affect physical function (such as kidney disease and liver disease), and even genetic differences.
Genetic differences in particular affect the metabolism of individuals; those with fast metabolisms quickly metabolize the drug, leading to the amount of the drug being not enough to exert its desired effect. Conversely, those with slow metabolisms struggle to internally metabolize the drugs, which will cause toxins to accumulate in the body, leading to side effects or adverse reactions.
As each person will have a varied response to medication, it is thus pivotal for an individual to acquire a personalized drug prescription appropriate for themselves, taking into account their genetic makeup and other personal factors.
Reduce the side effects of drugs with pharmacogenetics
From the "symptomatic", one-size-fits-all prescription of traditional medicine to the "symptom and gene" prescription of precision medicine, personalized medication is a major medical trend in recent years. Under traditional medical treatment, patients need to go through constant testing, drug changes, and dosage adjustments to reduce side effects or ineffective medication. They are all formulated by doctors or pharmacists based on experience, and the efficiency is low. Under precision medicine and through pharmacogenetics, we understand that individual genetic differences can lead to different drug reactions. We can directly rule out treatment options that are not suitable for patients, and recommend the most effective drug type and dosage for each patient to the doctor or pharmacist.
Ultimately, drug responses are very complex and can be influenced by many factors, including genetics. After obtaining a drug genetic test report, you must find feasible medication plans under the guidance of a doctor or pharmacist. Please do not adjust the drug dosage or stop the drug yourself.