Hereditary cancer test

Investigate lifetime cancer risk

Some genetic mutations are linked to a higher risk of developing certain types of cancers. In a hereditary cancer, certain patterns of cancer may happen within family members. Individuals with a hereditary cancer gene will have a higher overall cancer risk than the general population and higher risk of developing cancer at an early age. The cancers with high genetic correlations include breast, ovarian, gastric, prostate, and colorectal cancers.

13% of cancer patients have a pathogenic mutation originated from their family.

30% of cancer patients had treatment modifications due to inheritable mutations.

JAMA Oncol. 2021 Feb 1;7(2):230-237. doi: 10.1001/jamaoncol.2020.6252

Who should consider the test?

For someone with cancer in their family history to see if they carry a gene mutation linked to a higher chance of developing cancer.
For someone already diagnosed with cancer to see if a gene mutation exists within other family members.
For family members of someone known to have an inheritable gene mutation linked to a higher risk of cancer to see if they carry the same mutation.

What do you do when you have a cancer gene mutation?

If you have tested positive for a cancer gene mutation, it does not mean you definitely will have cancer. However, your chance of developing cancer will be higher than the general population.

If you carry a gene mutation linked to a higher chance of developing cancer, you should:


Start cancer screening tests as soon as possible

Screen for cancer more frequently

Closely watch out for any cancer symptoms

Learn about options that reduce cancer risk

The process

1

Order and receive a saliva collection kit.

2

Register the sample collection tube barcode online, then take a sample.

3

Mail the kit back to Codex’s laboratory for analysis.

4

Results are provided to you securely on the Codex website within six weeks from receipt of sample.

A high accuracy standard

Steps Accuracy
DNA sequencing 99.9%
Variant calling – SNP >99%*
Variant calling – Indel >99%*
Variant Annotation 100%#

* Passed GenQA/UK NEQAS external quality assurance

# The interpretation of sequencing variants is based on the current understanding of the variants at the time it was observed, which may change over time as more information about the genes becomes available. Not all variants are represented in this report.