Is there a chance that everyone's medication effectiveness and side effects are different?
Everyone has a different drug response which can be influenced by external or internal factors. Examples of external factors include whether individuals are taking other drugs at the same time, which may lead to drug interactions; individuals may also experience other drug reactions after eating foods and drinks which influence the function of drugs taken. On the other hand, internal, personal factors that affect drug response can consist of height, weight, age, other diseases which affect body function (such as kidney disease, liver disease), and even genes. The above factors will affect each person's response to drugs, and the type and dosage of drugs prescribed needs to account for individual differences to maximize effectiveness.
In particular, gene mutations can change the expression and/or function of drug metabolizing enzymes, transport proteins, and drug targets, leading to differences in drug response. Simply put, genetic differences affect an individual's metabolism. For those with fast metabolism, the body quickly metabolizes the drug; this may lead to reduced drug efficacy as it is processed too quickly. Conversely, for individuals with slow metabolism, drugs are excreted too slowly; this may cause toxins to accumulate in the body, causing side effects or adverse reactions.
Trends in personalized medicine: understanding genetic testing for drug response
Through drug genetic testing, it is possible to check whether the patient has genetic mutations that affect drug response, which can help improve the efficacy of medication, save the cost of medication changes, avoid adverse reactions, and reduce side effects.
Codex’s drug genetic testing is followed by a report analysis according to the latest pharmacogenetics guidelines, including the Clinical Pharmacogenetics Implementation Association (CPIC), the Dutch Pharmacogenetics Working Group (DPWG), the U.S. Food and Drug Administration (FDA), and European Public Assessment Reports (EPARs) of the European Medicines Agency (EMA). With genetic analysis supported by scientific research, Codex provides medication guidelines for patients, such as recommended drug changes or drug dosage adjustments.
Ultimately, drug responses are very complex and can be influenced by many factors, including genetics. After obtaining a drug genetic test report, you must find feasible medication plans under the guidance of a doctor or pharmacist. Please do not adjust the drug dosage or stop the drug yourself.