Lewy Body Dementia Shared Risk Genes with Alzheimer’s and
APOE and B1N1 gene, which are the known risk genes of
Alzheimer’s disease, were found to be related to Lewy Body Dementia.
GBA, SNCA, and TMEM175 genes are associated with
the risk of developing Parkinson’s disease and Lewy Body Dementia. In
this study, B1N1 and TMEM175 were first implicated in Lewy
Body Dementia pathogenesis.
This study has provided a deeper understanding of Lewy Body Dementia. It
also pinpoints the importance of molecular diagnosis. By determining the
specific dementia-causing gene, it helps clinicians to plan personalized
treatments for LBD patients.