CoGenesis® BRCA-Pro is an 11-gene test for hereditary breast and ovarian
cancers. It includes genes linked to a higher chance of developing breast
and ovarian cancer: BRCA1, BRCA2, ATM, TP53, CHEK2, PTEN, CDH1, STK11,
PALB2, RAD51C, RAD51D genes. This test helps you to understand your risk
level of developing breast and ovarian cancer throughout your lifetime.
1 in every 14 females in Hong Kong will have breast cancer in their
lifetime.1
About 5% to 10% of breast cancers are hereditary.2
If you have a breast cancer gene mutation, your chance of getting breast
cancer is 10 times higher than the general population.3
About hereditary ovarian cancer
About 10% to 15% of ovarian cancers are hereditary.2
If you have an ovarian cancer gene mutation, your chance of getting
ovarian cancer is 50 times higher than the general population.
3
If you have tested positive for a breast and ovarian cancer gene
mutation, it does not mean you definitely will have breast and ovarian
cancer. However, your chance of getting breast and ovarian cancer will
be higher than the general population.
What can you do if you belong to the high-risk population?
Start breast and ovarian cancer screening tests as soon as
possible
Screen for breast and ovarian cancer more frequently
Closely watch out for any breast and ovarian cancer symptoms
Learn about options that reduce breast and ovarian cancer risk
Early detection genetic variation and prevention can reduce the
risk of breast cancer by 90%, and risk of ovarian cancer by 85%.
Hong Kong Hereditary Breast Cancer Family Registry. Hereditary Cancers.
Genetic testing should be made available to all newly diagnosed breast
cancer patients.
Manahan, E. et al. Annals of Surgical Oncology, 26,10 (2019)
All women diagnosed with epithelial ovarian cancer should have
germline genetic testing for BRCA1/2 and other ovarian cancer
susceptibility genes.
Konstantinopoulos PA, et al. Journal of Clinical Oncology, 38,11
(2020)
# The interpretation of sequencing variants is based on the current
understanding of the variants at the time it was observed, which may change
over time as more information about the genes becomes available. Not all
variants are represented in this report.
Source:
Hong Kong Cancer Registry, Hospital Authority. Female Breast Cancer in
2018. Last updated: Oct 2020.
Division of Cancer Prevention and Control, Centers for Disease Control and
Prevention.
