CoGenesis® Prostate

Hereditary prostate cancer test

CoGenesis® Prostate is an 11-gene test for hereditary prostate cancers. It includes genes linked to a higher chance of developing prostate cancer: ATM, BRCA1, BRCA2, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, PMS2, TP53 genes. It helps you to understand your risk level of developing prostate cancer throughout your lifetime.
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About hereditary prostate cancer


About 10% of prostate cancers are hereditary. 1

If you have a prostate cancer gene mutation, your chance of getting prostate cancer is 5 to 7 times higher than the general population. 2

If you have 1 close relative with prostate cancer, your chance of getting prostate cancer is 2 to 3 times higher than the general population. 3

Familial prostate cancer makes up about 20% of all prostate cancer. 3

If you have tested positive for a prostate cancer gene mutation, it does not mean you definitely will have prostate cancer. However, your chance of getting prostate cancer will be higher than the general population.

What can you do if you belong to the high-risk population?

  • Start prostate cancer screening tests as soon as possible
  • Screen for prostate cancer more frequently
  • Closely watch out for any prostate cancer symptoms
  • Learn about options that reduce prostate cancer risk

Not only in elderly men

  • Men with a prostate cancer gene mutation are prone to developing prostate cancer at a younger age
  • Prostate cancer patients with prostate cancer gene mutations can receive more extensive and early treatment than other patients

Prostate cancer gene mutation carriers should consider beginning PSA screening at age 40, and screening at annual intervals.

NCCN Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic (Version 1.2020)

A high accuracy standard

Steps Accuracy
DNA sequencing 99.9%
Variant calling – SNP >99%*
Variant calling – Indel >99%*
Variant Annotation 100%#

* Passed GenQA/UK NEQAS external quality assurance

# The interpretation of sequencing variants is based on the current understanding of the variants at the time it was observed, which may change over time as more information about the genes becomes available. Not all variants are represented in this report.

Source:

  1. American Cancer Society. Prostate Cancer Causes, Risk Factors, and Prevention.
  2. Cancer Research UK. Prostate Cancer Risk, Family history and genetic factors.

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