CoGenesis® Colo

Hereditary colorectal cancer test

CoGenesis® Colo is a 12-gene test for hereditary colorectal cancers. It includes genes linked to a higher chance of developing colorectal cancer: APC, BMPR1A, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, SMAD4, STK11, TP53 genes. It helps you to understand your risk level of development colorectal cancer throughout your lifetime.
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About hereditary colorectal cancer


1 in every 20 males in Hong Kong will have colorectal cancer in their lifetime.1

1 in every 32 females in Hong Kong will have colorectal cancer in their lifetime. 1

An estimated 35% of colorectal cancers are hereditary. 2

If you have 1 close relative with colorectal cancer, your chance of getting colorectal cancer is 2-3 times higher than the general population. 3

If you have tested positive for a colorectal cancer gene mutation, it does not mean you will have colorectal cancer. However, your chance of getting colorectal cancer will be higher than the general population.

What can you do if you belong to the high-risk population?

  • Start colorectal cancer screening tests as soon as possible
  • Screen for colorectal cancer more frequently
  • Closely watch out for any colorectal cancer symptoms
  • Learn about options that reduce colorectal cancer risk

The 5-year survival rate of colorectal cancer is about 90% for those who found it at an early stage. 4

​​American Cancer Society. Colorectal Cancer Early Detection, Diagnosis, and Staging.

Common hereditary colorectal cancer syndromes

Lynch syndrome (Hereditary non-polyposis colorectal cancer, HNPCC)

General lifetime colorectal cancer risks up to 80%4

  • Suggested to perform colonoscopy every 1-2 years starting from age 20-254, 5

Familial Adenomatous Polyposis (FAP)

Accounts for about 1% of colorectal cancers 6, but 100% will develop into a malignant tumor 3

  • Suggested to perform sigmoidoscopy once a year starting from age 10-155
  • Suggested to consider performing preventive surgery before polyps turns into cancer

A high accuracy standard

Steps Accuracy
DNA sequencing 99.9%
Variant calling – SNP >99%*
Variant calling – Indel >99%*
Variant Annotation 100%#

* Passed GenQA/UK NEQAS external quality assurance

# The interpretation of sequencing variants is based on the current understanding of the variants at the time it was observed, which may change over time as more information about the genes becomes available. Not all variants are represented in this report.

Source:

  1. Hong Kong Cancer Registry, Hospital Authority. Colorectal Cancer in 2018. Last updated: Oct 2020.
  2. Monahan KJ, Bradshaw N, Dolwani S Hereditary CRC guidelines eDelphi consensus group, et alGuidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)Gut 2020;69:411-444.2​
  3. Burt R. Inheritance of Colorectal Cancer. Drug Discov Today Dis Mech. 2007;4(4):293-300. doi:10.1016/j.ddmec.2008.05.004
  4. American Society of Clinical Oncology (ASCO). Lynch Syndrome 01/2020. https://www.cancer.net/cancer-types/lynch-syndrome
  5. National Comprehensive Cancer Network. NCCN Guideline. Genetic/ Familial High-Risk Assessment: Colorectal.
  6. American Cancer Society. Colorectal Cancer Causes, Risk Factors, and Prevention.

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